Medical guide wire assembly comprising a guide wire having a proximal end and a distal end, at least one physiology parameter sensor, and that the proximal end of the guide-wire is provided with an elongated connector part, having connection electrodes, for insertion into a connector housing provided with an elongated tubing adapted to achieve electrical and mechanical connection to the elongated connector part, the connector housing is in its turn electrically or wirelessly connectable to a physiology monitor. The guide wire is provided with a core wire running essentially along the entire guide wire. A sensor signal processing circuitry is arranged in connection with the physiological sensor and is adapted to generate a processed sensor signal in response of a sensed parameter. The sensor signal processing circuitry comprises a modulation unit arranged to modulate the processed sensor signal and to generate a modulated sensor signal. The assembly comprises exactly two micro-cables that are connected to the sensor signal processing circuitry, the micro-cables run along the guide wire and are connected to the connection electrodes of the connector part, wherein one of the core wire and the two micro-cables are actively used when transferring the processed and modulated sensor signal to the connector housing.
