[PROBLEMS] To provide a glycyrrhizin/aminoacetic acid/cysteine combinationdrugcontaining an active ingredient in high concentration and excelling instability and safety.[MEANS FOR SOLVING PROBLEMS] Stability at compounding of active ingredient inhigh concentration has been improved by avoiding the addition of sulfite saltshavingbeen used as a stabilizer in existing products. As glycyrrhizin high-concentrationpreparations, there is provided a drug composition comprising 8 to 16 mg/mL ofglycyrrhizin, 3 to 6 mg/mL of cysteine and 80 to 160 mg/mL of aminoacetic acidwhereinno sulfite salts are added as an additive.