California Institute of Technology;The Brigham and Women's Hospital, Inc.
发明人:
Sarkis K. Mazmanian,Sung-Eun Lee,Dennis L. Kasper
申请号：
US13573695
公开号：
US09057070B2
申请日:
2012.10.03
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided is an isolated B. fragilis bacterial cell producing a native capsular polysaccharide A (PSA), wherein the cell is incapable of producing capsular polysaccharides PSB, PSC, PSD, PSE, PSF, PSG, and PSH because the cell's biosynthetic genes for native capsular polysaccharides PSB, PSC, PSD, PSE, PSF, PSG, and PSH have been deleted from the cell's genome. The isolated or wild type B. fragilis cell, or an extract obtained from said B. fragilis cell, can be used to treat individuals with inflammation.
