HOOCK, Ralf,KORADIN, Christopher,PLETSCH, Andreas,EHRESMANN, Manfred,BONNEKESSEL, Melanie,KAEDING, Thomas,Schröder, Hartwig,REICHERT, Wolfgang
申请号：
DK14700640
公开号：
DK2945949T3
申请日:
2014.01.15
申请国别(地区):
DK
年份:
2019
代理人:
摘要：
The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11-trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I)； iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor；and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).
