compound, use of a compound, methods of prevention, treatment, amelioration or prophylaxis of physiological disorders or diseases, and treatment or amelioration of cosmetic indications； and, pharmaceutical composition.
GUNNAR GRUE-S ORENSEN,KRISTOFFER M AANSSON,PER VEDS O,THOMAS HÖGBERG,THOMAS VIFIAN,XIFU LIANG
申请号：
BR112013015855
公开号：
BR112013015855A2
申请日:
2011.12.22
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7； or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8； or R is X wherein X is &mdash；NR11R12； and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use&mdash；alone or in combination with one or more other pharmaceutically active compounds&mdash；in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
