compound, use of a compound, methods of prevention, treatment, amelioration or prophylaxis of physiological disorders or diseases associated with hyperplasia, neoplasia or dysplasia, and treatment or amelioration of cosmetic indications； and, pharmaceutical composition

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专利权人:

LEO LABORATORIES LIMITED

发明人:

Bjarne Nørremark,Carsten Ryttersgaard,Gunnar Grue-Sørensen,Kristoffer Månsson,Thomas Högberg,Xifu Liang

申请号：

BR112014032244

公开号：

BR112014032244A2

申请日:

2013.06.21

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “compounding, use of a compound, methods for the prevention, treatment, amelioration or prophylaxis of physiological disorders or diseases associated with hyperplasia, neoplasia or dysplasia, and treatment or improvement of indication. Cosmetic compositions, and pharmaceutical composition The present invention relates to a compound according to the formula (i) wherein r represents optionally substituted heteroaryl and its pharmaceutically acceptable salts thereof. pharmaceutically acceptable and physiologically cleavable esters. The invention further relates to intermediates for the preparation of said compounds, said compounds for use in therapy, pharmaceutical compositions comprising said compounds, methods for the treatment of diseases, for example diseases associated with hyperplasia, neoplasia or dysplasia, with said compounds, methods of treating cosmetic indications with said compounds and the use of said compounds in the manufacture Medication.1 / 1 resumo “composto, uso de um composto, mã‰todos de prevenã‡ãƒo, tratamento, melhora ou profilaxia de distãšrbios fisiolã“gicos ou doenã‡as associadas com hiperplasia, neoplasia ou displasia, e de tratamento ou melhora de indicaã‡ã•es cosmã‰ticas, e, composiã‡ãƒo farmacãšuticaâ€� a presente invenã§ã£o refere-se a um composto de acordo com a fã³rmula (i) em que r representa heteroaril opcionalmente substituã­do e seus 1 respectivos sais farmaceuticamente aceitã¡veis, hidratos, solvatos ou respectivos ã©steres farmaceuticamente aceitã¡veis e fisiologicamente clivã¡veis. a invenã§ã£o refere-se ainda a intermediã¡rios para a preparaã§ã£o dos referidos compostos, aos referidos compostos para uso em terapia, a composiã§ãµes farmacãªuticas compreendendo os referidos compostos, aos mã©todos de tratamento de doenã§as, por exemplo, doenã§as associadas com hiperplasia, neoplasia ou displasia, com os referidos compostos, aos mã©todos de tratamento das indicaã§ãµes cosmã©ticas com os referidos compostos e ao uso d

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