Parvesh Sharma,Scott Chang Brown,Niclas Bengtsson,Glenn A. Walter,Nobutaka Iwakuma,Edward W. Scott,Stephen R. Grobmyer,Swadeshmukul Santra,Brij M. Moudgil
申请号：
US13582226
公开号：
US20130108552A1
申请日:
2011.02.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The subject invention provides novel fluorescent core-shell nanoparticles comprising an encapsulated fluorescent core comprising an ionically bound fluorescent dye and a metal oxide shell. In one exemplary embodiment of the invention a core containing indocyanine green (ICG) with a silica shell that displays excellent photostability for generation of a near infrared fluorescence signal. The fluorescent core-shell nanoparticle can be further modified to act as an MRI, x-ray, or PAT contrast agent. The ICG nanoparticles can also be used as photodynamic therapeutic agent. Other embodiments of the invention directed to methods of making the novel core-shell nanoparticles and to the use of the core-shell nanoparticles for in vitro or in vivo imaging.
