MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

IGAWA, Tomoyuki,YOSHIHASHI, Kazutaka,SAMPEI, Zenjiro,KOJIMA, Tetsuo,SOEDA, Tetsuhiro,MUTO, Atsushi,KITAZAWA, Takehisa,NISHIDA, Yukiko,IMAI, Chifumi,SUZUKI, Tsukasa

申请号：

MYPI 2013700794

公开号：

MY166429A

申请日:

2011.11.17

申请国别(地区):

MY

年份:

2018

代理人:

摘要：

Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X byactivated blood coagulation factor IX, were produced. Fromthese antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

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