Edward R. M. OBrien,Katey Rayner,Yong-Xiang Chen,Xiaoli Ma
申请号：
US12939065
公开号：
US08343916B2
申请日:
2010.11.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A method of reducing cholesterol in a subject is provided. The method may be used to decrease serum cholesterol and/or arterial wall cholesterol. The method comprises administering a therapeutically effective amount of heat shock protein 27 (HSP27), or a co-factor, variant or analogue thereof. The method may be used to treat, prevent or reverse cardiovascular disease (including atherosclerosis) to decrease atherosclerotic lesion formation or rupture to decrease apoptosis within a plaque to decrease macrophage accumulation and/or to reverse the accumulation of atherosclerotic plaque mass in a subject. Kits and pharmaceutical compositions comprising HSP27 for preventing or treating of cardiovascular disease, such as atherosclerosis, are also provided.
