The bright Shi mono- Seed compounds System Prepare of this Hair control Treatment lung cancer, breast cancer Ji the Drug objects of sub- Palace Neck gland cancer purposes, The compound As 7-chloro-6-piperidin-1-yl-quinoline-5,8-dione ization Learn:Chloro- six Hydrogen pyridine -1- yl-quinolines -5, the 8- diketone of 6- of 7-), there is Hua Learn formula As C14H13ClN2O2 , Jane Said As PT-262, The Drug objects Steady to determine flesh Move Dan Bai Silk effects, the polymerization for causing flesh Move Dan Bai Silk Iso normal, the Fine Bao La Long of the carcinogenic Fine born of the same parents of GuideIn addition, PT-262 has anticancer activity, Hui hinders the existence road Trail of Ras-ERK albumen in Broken cancers Fine born of the same parents, causes the effect of the apoptosis of cancer Fine born of the same parents, breaks the activation of Bad Li Line Body films , Cu Jin caspase-3 albumenAnother PT-262 Hui inhibit the content of 1 With phosphorylation cdc2 albumen (phospho-cdc2) of Xun Ring protein Bs, and the carcinogenic Fine Bao Week phases Ting Zhi With of Guide inhibit cancer Fine Bao Sheng Long.本發明是一種化合物在製備治療肺癌、乳腺癌及子宮頸腺癌之藥物的用途,該化合物為7-chloro-6-piperidin-1-yl-quinoline-5,8-dione(化學名:7-氯-6-六氫吡啶-1-基-喹啉-5,8-二酮),其化學式為C14H13ClN2O2,簡稱為PT-262,該藥物具有穩定肌動蛋白絲作用,造成肌動蛋白絲異常的聚合,導致癌細胞的細胞拉長;此外,PT-262具有抗癌活性,會阻斷癌細胞中Ras-ERK蛋白之生存路徑,造成癌細胞的凋亡的作用,破壞粒線體膜,促進caspase-3蛋白的活化;另PT-262會抑制循環蛋白B1與磷酸化cdc2蛋白(phospho-cdc2)的含量,導致癌細胞週期停止與抑制癌細胞生長。
