Systems and methods for reconfigurable handheld laser treatment systems are provided. In one embodiment, a reconfigurable handheld laser treatment system comprises: a base unit; a handset that includes a attachment chamber having an attachment aperture, and a laser source arranged to project optical energy into the attachment chamber, the handset coupled to the base unit; an attachment having an adapter interface compatible with insertion into the attachment chamber; a trigger sensor coupled to logic that controls activation of the laser array; and an attachment sensor arranged to detect insertion of the adapted interface into the attachment chamber through the attachment aperture. The logic enables activation of the laser array when the attachment sensor detects an authorized attachment inserted into the attachment aperture. The logic disables activation of the laser array when the attachment sensor fails to detect an authorized attachment inserted into the attachment aperture.