Evofosfamide (TH-302) or an analog thereof has a specific inhibitory effect on a cell having a specific gene mutation, in particular on a DNA repair-damaged cell. The cell or tissue has at least one or more gene mutations in BRCA1, BRCA2, FANCD1, FANCD2, ATM, ATR, CHEK1, CHEK2, CTP, BARD1, BRIP1, PALB2, RAD51D, RAD51C, RAD52, RAD54, RAD55, RAD57, FAM175, NBN, Rad50, MER11, p53, NBS1, XRS2, XRCC2, XRCC3, ERCC1, ERCC2, ERCC3, ERCC4, XRCC1, Ku80, MHS6, MGMT, PARP, and ERCC5. For this, a medical use of evofosfamide (TH-302) or an analog thereof in treating tumors or cancer in a cancer patient having the specific gene mutation(s) is provided.埃夫索胺（TH-302）或其類似物對於特定基因變異的細胞具有特異性的抑制作用，具體而言就是DNA修復受損的細胞，該細胞或組織至少有BRCA1、BRCA2、FANCD1、FANCD2、ATM、ATR、CHEK1、CHEK2、CTP、BARD1、BRIP1、PALB2、RAD51D、RAD51C、RAD52、 RAD54、 RAD55、 RAD57、FAM175、NBN、Rad50、MER11、p53、NBS1、 XRS2、XRCC2、XRCC3、ERCC1、ERCC2、ERCC3、ERCC4、XRCC1、Ku80、MHS6、MGMT、PARP或ERCC5中一個基因突變或更多個基因突變。為此提供了埃夫索胺（TH-302）或其類似物在治療上述特定基因變異的癌症患者的腫瘤、癌症疾病中的醫藥用途。
