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LIGANDS AND METHODS FOR ISOLATING OR REMOVING PROTEINS
专利权人:
发明人:
Stephan T. Kiessig,Dirk Muller,Marc Mazur
申请号:
US14484907
公开号:
US20160067674A1
申请日:
2014.09.12
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present disclosure relates generally to sorbents for binding proteins from blood plasma comprising a solid carrier material and an oligopeptide immobilized thereon, which selectively binds the protein from the blood plasma, and to a method for separating autologous proteins from blood plasma wherein the blood plasma is brought in contact with a corresponding sorbent, the desired protein is allowed to bind to the sorbent, the sorbent is separated from the plasma and the protein is subsequently separated from the sorbent. Corresponding sorbents and method allows for the selective isolation of specific blood plasma proteins directly from the blood plasma without having to conduct a tedious fractionation. This significantly improves the protein yield and provides a highly effective isolation of blood plasma protein constituents such as IgG, albumin, factor V and factor VIII in a simple, cheap and time-efficient process.
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