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4- (1,2,4-dioxazol-3-yl) benzamides for the treatment of diabetes and obesity
专利权人:
DAIICHI SANKYO COMPANY; LIMITED
发明人:
YAMANOI, SHIGEO,NAMIKI, HIDENORI,KATAGIRI, TAKAHIRO,KAGECHIKA, KATSUJI,HONDA, TAKESHI,MATSUMOTO, KOJI,NAKASHIMA, RYUTARO
申请号:
ES10806468
公开号:
ES2459950T3
申请日:
2010.08.04
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound represented by the general formula (I): ** Formula ** in which R1 represents a hydrogen atom or the C1-C6 alkyl group substituted with one or two substituents selected from a subgroup substituent; the substituent subgroup is the group consisting of a C1-C6 alkoxy group; a C1-C6 alkoxycarbonyl group, a hydroxyl group that may be substituted with a substituent selected from a subgroup substituent and a carboxyl group; the substituent subgroup is the group consisting of a C1-C6 alkoxycarbonyl group substituted with one or two substituents selected from a β substituent group, and a 4- to 6-membered heterocyclic carbonyl group that may be substituted with a C1-C6 alkyl group; the substituent subgroup β is the group consisting of a hydroxyl group, an amino group, a group (C1-C6 alkyl) amino, a di (C1-C6 alkyl) amino group, a carbamoyl group, a phenyl group and a heterocyclic group from 4 to 6 members; R2 represents a hydrogen atom or a C1-C6 alkyl group that may be substituted with a hydroxyl group; or R1 and R2, together with the nitrogen atom to which R1 and R2 are attached, can be joined to form an azetidino group, a pyrrolidino group or a morpholino group, in which the azetidino group, the pyrrolidino group or the morpholino group can be substituted with a hydroxyl group or a C1-C6 hydroxyalkyl group; R3 and R4 each independently represent a C1-C6 alkyl group; R5 represents a halogen atom or a C1-C6 alkyl group; R6 represents a halogen atom; m and n each independently represent an integer from 0 to 4; V and W represent both CH; and X, Y and Z each independently represent CH or N, or a pharmaceutically acceptable salt thereof.Un compuesto representado por la fórmula general (I):**Fórmula** en la que R1 representa un átomo de hidrógeno o el grupo alquilo C1-C6 sustituido con uno o dos sustituyentes seleccionados de un subgrupo sustituyente ; el subgrupo sustituyente es el grupo que consiste en un grupo alcoxi C1-C6; un grupo alcoxicarbonilo C1-C6, un grupo hi
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