To provide a keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit whereby the regrowth of a keratotic plug can be effectively inhibited without causing skin irritation. A keratotic plug regrowth inhibition agent, characterized in containing: (a) a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof； (b) a specific surfactant (for example, fatty acid soap, higher alkyl sulfate ester salt, polyoxyalkylene phytosterol, or the like)； and (c) a specific skin irritation mitigation agent (for example, POE/POP dimethyl ether, tranexamic acid, pantothenyl ethyl ether, trimethyl glycine, glycylglycine, or the like). A keratotic plug regrowth inhibition method, in which a skin cleanser including a POE fatty acid ester is applied to the skin and thereafter a keratotic plug regrowth inhibition agent including a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof is applied to the skin； also, a keratotic plug regrowth inhibition kit comprising the skin cleanser and keratotic plug regrowth inhibition agent.本發明揭示一種角栓再生抑制劑，其特徵為含有(a)特定的酸(例如，乳酸、琥珀酸、檸檬酸等)或該等鹽、與(b)特定的界面活性劑(例如，脂肪酸石鹼、高級烷基硫酸酯鹽、聚氧化烯植物固醇等)、與(c)特定的抗皮膚粗糙改善劑(例如，POE‧POP二甲基醚、妥內散酸(Tranexamic acid)、泛醯乙基醚、三甲基甘胺酸、甘胺醯基甘胺酸等)。又，揭示含有POE脂肪酸酯之皮膚清潔劑適用於肌膚之後，含有特定的酸(例如，乳酸、琥珀酸、檸檬酸等)或該等鹽之角栓再生抑制劑適用於肌膚之角栓再生抑制方法、及前記皮膚清潔劑與角栓再生抑制劑所構成之角栓再生抑制組套。經由本發明，提供一種不會引起皮膚粗糙可以有效果地抑制角栓之再生之角栓再生抑制劑、角栓再生抑制方法、及角栓再生抑制組套。
