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IMMUNOGENS OF HIV-1 BROADLY NEUTRALIZING ANTIBODIES, METHODS OF GENERATION AND USES THEREOF
专利权人:
INTERNATIONAL AIDS VACCINE INITIATIVE;THE SCRIPPS RESEARCH INSTITUTE
发明人:
William R. Schief,Bruno E. Correia,Daniel W. Kulp,Ron Jacak
申请号:
US14642929
公开号:
US20150238594A1
申请日:
2015.03.10
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present application relates to immunogens of broadly neutralizing monoclonal antibodies specific for HIV-1, such as broad and potent neutralizing monoclonal antibodies specific for HIV-1 and their gernation and methods of use. Broad neutralization suggests that the antibodies can neutralize HIV-1 isolates from different individuals. Immunogens or vaccines which may elicit such antibody associated responses are useful in pharmaceutical compositions for the prevention and treatment of HIV, and for the diagnosis and monitoring of HIV infection.
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