BECK, Elizabeth Mary,BRODNEY, Michael Aaron,BUTLER, Christopher Ryan,O'NEILL, Brian Thomas
申请号：
ES14705878
公开号：
ES2640638T3
申请日:
2014.02.04
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I ** (See formula) ** in which R1 is hydrogen or methyl, wherein said methyl is optionally substituted with one to three fluorine； R2 is phenyl substituted with one to five R3； R3, at each occurrence, is independently selected from the group consisting of halogen, hydroxy, cyano, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C3-6 cycloalkoxy, C3-6 cycloalkyl - (CR4aR4b) m-, C3-6- cycloalkoxy (CR4aR4b) m-, C3-6- cycloalkyl (CR4aR4b) mO- or (4-6 membered heterocycloalkyl) - (CR4aR4b) m-； wherein said C1-6 alkyl, C1-6 alkoxy or C1-6-C1-6 alkoxy alkyl are each optionally substituted with one to three fluorine and wherein said C3-6 cycloalkyl, C3 cycloalkoxy moieties 6 and (4-6 membered heterocycloalkyl) are optionally substituted with one to three substituents independently selected from the group consisting of fluorine, methyl, fluoromethyl, difluoromethyl or trifluoromethyl； or two R3, when attached to adjacent carbon atoms of the phenyl, and taken together, can be - (CH2) n-O-, -O- (CH2) o-O- or - (CH2) p-； R4a and R4b are independently hydrogen, methyl, fluoromethyl, difluoromethyl, trifluoromethyl or methoxy； m at each occurrence is independently 0, 1 or 2； n is 2 or 3； o is 1 or 2； and p is 3 or 4； or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer.Un compuesto de Fórmula I **(Ver fórmula)** en la que R1 es hidrógeno o metilo, en la que dicho metilo está opcionalmente sustituido con uno a tres flúor； R2 es fenilo sustituido con uno a cinco R3； R3, en cada aparición, se selecciona independientemente entre el grupo que consiste en halógeno, hidroxi, ciano, alquilo C1-6, alcoxi C1-6, alcoxi C1-6-alquilo C1-6, cicloalcoxi C3-6, cicloalquil C3-6-(CR4aR4b)m-, cicloalcoxi C3-6- (CR4aR4b)m-, cicloalquil C3-6-(CR4aR4b)m-O- o (heterocicloalquil de 4 a 6 miembros)-(CR4aR4b)m-； en la que dicho alquilo C1-6, alcoxi C1-6 o alcoxi C1-6-C1-6alquilo están, cada uno de ellos, opcionalmente sustituidos con uno a tres flú
