Berta Ponsati Obiols;Juan Cebrian Puche;Nuria Almiñana Domenech;Antonio Ferrer Montiel;Wim Van Den Nest;Cristina Carreño Serraïma;Jimena Fernandez Carneado
发明人:
Cristina Carreño Serraïma,Berta Ponsati Obiols,Wim Van Den Nest,Jimena Fernandez Carneado,Antonio Ferrer Montiel,Juan Cebrian Puche,Nuria Almiñana Domenech
申请号：
US12447136
公开号：
US09464129B2
申请日:
2007.10.24
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to peptides of general formula (I):R1-AA-R2 (I)which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group； and R2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R1 is H or acetyl, R2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.
