immunoglobulin single variable domain, isolated polypeptide, binder, fusion protein, isolated nucleic acid, isolated nucleic acid molecule, vector, host cell, methods for making a polypeptide and for treating and / or preventing a condition, pharmaceutical composition, use of a single variable domain, and pulmonary dispensing device.
Adriaan Allart Stoop,Caroline J. Dimech,Rudolf Maria De Wildt,Steve Holmes
申请号：
BR112012001977
公开号：
BR112012001977A2
申请日:
2010.07.27
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. The disclosure also provides a polypeptide, ligand or pharmaceutical composition for treating a disease associated with TGFbeta signaling and a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis, liver fibrosis, including cirrhosis and chronic hepatitis, rheumatoid arthritis, ocular disorders, or fibrosis of the skin, including keloid of skin, and kidney such as nephritis, kidney fibrosis and nephrosclerosis, and a vascular condition, such as restenosis.
