Anders Nykjær;Kimmo Jensen;Simon Glerup Pedersen;Ulrich Bølcho
发明人:
Simon Glerup Pedersen,Ulrich Bølcho,Kimmo Jensen,Anders Nykjær
申请号：
US13140515
公开号：
US08703125B2
申请日:
2009.12.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to methods for modulating the activity of one or more Vps10p-domain receptors selected from the group consisting of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3, in an animal and methods for preparation of a medicament for the treatment of mental and behavioral disorders. The modulation is carried out by inhibiting or promoting the binding of ligands to the Vps10p-domain receptor. In vitro and in vivo methods for screening for agents capable of modulation of said Vps10p-domain receptor activity are also provided. The invention further-more relates to methods of altering expression of said receptors in vivo.
