Simon Glerup Pedersen,Ulrich Bolcho,Kimmo Jensen,Anders Nykjaer
申请号：
US15584972
公开号：
US20170240611A1
申请日:
2017.05.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to methods for modulating the activity of one or more Vps10p-domain receptors selected from the group consisting of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3, in an animal and methods for preparation of a medicament for the treatment of mental and behavioral disorders. The modulation is carried out by inhibiting or promoting the binding of ligands to the Vps10p-domain receptor. In vitro and in vivo methods for screening for agents capable of modulation of said Vps10p-domain receptor activity are also provided. The invention furthermore relates to methods of altering expression of said receptors in vivo.
