Provided is a method for reducing the infectiousness of abnormal prion proteins. In this method for reducing the infectiousness of abnormal prion proteins, abnormal prion proteins are brought into contact with functional mineral water that contains an electromagnetic radioactive mineral component, thereby reducing the infectiousness of abnormal prion proteins. Also provided is a pharmaceutical composition for the preventive therapy of prion disease, the composition containing, as an active ingredient, the functional mineral water that contains an electromagnetic radioactive mineral component.本發明係提供使異常型普立昂蛋白所具有之感染力減少的方法。一種減低異常型普立昂蛋白之感染力的方法,其係使異常型普立昂蛋白,及包含電磁波放射性礦物質成分之礦物質機能水進行接觸,而使異常型普立昂蛋白所具有之感染力減少。一種預防治療普立昂疾病用之醫藥組成物,其係含有包含電磁波放射性礦物質成分之礦物質機能水作為有效成分。