AZAD, Md Abul Kalam,PANDEY, Gyanendra,SINGH, Kaptan,PRASAD, Mohan
申请号：
IBIB2016/050529
公开号：
WO2016/125080A3
申请日:
2016.02.02
申请国别(地区):
IB
年份:
2016
代理人:
摘要：
The present invention provides processes for the preparation of baricitinib of Formula I and an intermediate of Formula V. The present invention also provides the use of the intermediate of Formula V for the preparation of baricitinib. The present invention provides an environmentally friendly, cost-effective, and industrially advantageous process for the preparation of baricitinib of Formula I. The process of the present invention involves the use of an environmentally benign heterogeneous catalyst, such as a zeolite. The use of a zeolite as a catalyst is beneficial for large scale synthesis, owing to its inexpensive nature, ease of handling, ease of isolation of the product, high reaction yields, and recyclability.La présente invention concerne des procédés de préparation de baricitinib de Formule I, et un intermédiaire de Formule V. La présente invention concerne également l'utilisation de l'intermédiaire de Formule V pour la préparation de baricitinib.
