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PROCÉDÉ POUR LA PRÉPARATION D'UN INTERMÉDIAIRE POUR LA SYNTHÈSE DU MÉDICAMENT ANTITUMORAL NIRAPARIB ET INTERMÉDIAIRE POUR LA SYNTHÈSE DE CELUI-CI
专利权人:
Zai Lab (Shanghai) Co.; Ltd.
发明人:
申请号:
EP18867225.7
公开号:
EP3694836A1
申请日:
2018.10.12
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
Disclosed is a process for preparing an intermediate of anti-tumor drug niraparib and an intermediate thereof. The present invention discloses a process for preparing compound (f), which comprises conducting a cyclization reaction of compound (e) in a solvent and in the presence of a base to give compound (f). The process of the present invention does not involve the steps of catalytic reduction or catalytic coupling reaction of precious metals and chiral separation, which has advantages such as low equipment requirements, simple operation, favorable industrial production, avoiding waste liquid containing heavy metals and phosphorus, low cost and high product ee value.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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