BLACKABY, Wesley Peter,DE KORT, Martin,ENTHOVEN, Mark,HINCHLIFFE, Paul Stuart,POULIE, Christian Bernard Matthijs,TIMMERS, Cornelis Marius,VERKAIK, Saskia
申请号：
ES12762256
公开号：
ES2585653T3
申请日:
2012.09.14
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound according to Formula I ** Formula ** or a pharmaceutically acceptable salt thereof, wherein YX is CH2-CH2, -C (O) O- or -CH2OR2 is phenyl, (C1-6) alkyl, heteroaryl (C2-8), benzoyl, heteroaryl (C2-8) carbonyl, alkoxy (C1-8), cycloalkyl (C3-6), cycloalkoxy (C3-6), all alkyl or alkoxy moieties thereof may optionally be substituted with one or more substituents selected from R10 and the phenyl or heteroaryl moieties thereof may be optionally substituted with one or more substituents selected from R12, or R2 is (C2-6) alkenyl, (C2-6) alkynyl, alkylcarbonyl ( C1-6), alkenylcarbonyl (C2-6), alkynylcarbonyl (C2-6), cycloalkyl (C3-6) carbonyl, alkenoxy (C3-6), cycloalkyl (C3-6) alkoxy (C1-4), phenylalkoxy (C1 -4) or heteroaryl (C2-8) alkoxy (C1-4)； R6 is hydroxy or H, or R6 is alkyl (C1-6), alkenyl (C2-6), alkynyl (C2-6), alkoxy (C1-4), alkenoxy (C3-6), cycloalkyl (C3-6) (C1-4) alkoxy, (C3-6) cycloalkoxy, heterocycle (C3-6) alkoxy (C1-4) alkoxy, halogen, cyano, alkyl or alkoxy moieties thereof may be optionally substituted with one or more substituents selected from R10, or R6 together with R7 is -O- (CH2) nO- in which n is 1-3 and in which the CH2 moiety may be optionally substituted with one or more (C1-3) alkyl substituents or R6 and R7 they can be attached in a cycloalkyl ring (C3-6)； R7 is hydroxy, H, or R7 is (C1-6) alkyl, (C2-6) alkenyl, (C2-6) alkynyl, (C1-4) alkoxy, (C3-6) alkenoxy, (C3-6) cycloalkyl , cycloalkyl (C3-6) alkoxy (C1-4), cycloalkoxy (C3-6), heterocycloalkyl (C3-6) alkoxy (C1-4), heterocycloalkyl (C3-6), heterocycloalkylcarbonyl (C2-6), (di ) (C1-4) alkylcarbonyl or heterocycloalkyl (C2-6) alkyl, alkyl, alkoxy or (hetero) cycloalkyl moieties thereof may be optionally substituted with one or more substituents selected from R11, or R7 is heteroaryl (C2-8 ), phenyl, phenylalkoxy (C1-4), heteroaryl (C2-8) alkoxy (C1-4), the phenyl or heteroaryl moieties thereof may be optionally substituted with one or more substituents selected from R11； R8 is H
