Refers to Derivatives of 3 - espirociclica piperidine compounds of formula (i) where X1 is nrx1 (crx1h) or n, N, where RX1 is H or alkyl (C1 - C6) n is 0 OR 1 x2 is n or CH, C M is 1 or 2 p is 0 OR 1 and NR1 or, where R1 is H, alkyl (C1 - C6), haloalquilo (C1 - C6), cycloalkyl (C3 C6), among other S 2a is - - - -, phenyl heteroaryl of 5 to 6 members, a cycloalkyl (c5-c6), among others.There is a Link, among others R2B is H or alkyl (c1-c4) R3 and R4 are each h, alkyl, cycloalkyl (C1 - C6) (C3 and C6), among others, R6 and R7 are each h, alkyl (C1 - C6, hidroxialquilo (C1) - C6) or haloalquilo (C1 - C6) R5 is phenyl heteroaryl 5 to 6 members, cycloalkyl (C3 C6), among other S.Preferred compounds are: 2 - amino - N - [(R) - 1 - benciloximetil - 2 - (2 - methyl - 2 - oxo - 4 - phenyl - 2.7 - Grabarsky, ITs The Wrong Guy spiro [4.5] dec 7 - 2 - oxo - il) ethyl] - 2 - methyl - 2 - propionamide amino - N - ((2R) - 3 - (Benzyloxy) - 1 - (4 - (4-fluorophenyl) - 2 - methyl - 2 - oxo - 2.7 - diazaespiro [4.5] decan - 7 - il - 1 - 2 - oxopropan) - yl) - 2 - metilpropanamida among others. It also relates to a Pharmaceutical composition.These compounds are still the ghrelin receptor agonists useful in the treatment of functional dyspepsia, gastroparesis, short bowel syndromeSE REFIERE A COMPUESTOS DERIVADOS DE PIPERIDINA 3-ESPIROCICLICA DE FORMULA (I) DONDE X1 ES (CRx1H)n, NRx1 O N, EN DONDE Rx1 ES H O ALQUILO(C1-C6) n ES 0 O 1 X2 ES CH, N O C m ES 1 O 2 p ES 0 O 1 Y ES NR1 U O, EN DONDE R1 ES H, ALQUILO(C1-C6), HALOALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS R2a ES -A-FENILO, -A-HETEROARILO DE 5 A 6 MIEMBROS, -A-CICLOALQUILO(C5-C6), ENTRE OTROS, EN DONDE A ES UN ENLACE, ENTRE OTROS R2b ES H O ALQUILO(C1-C4) R3 Y R4 SON CADA UNO H, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS R6 Y R7 SON CADA UNO H, ALQUILO(C1-C6), HIDROXIALQUILO(C1-C6) O HALOALQUILO(C1-C6) R5 ES FENILO, HETEROARILO DE 5 A 6 MIEMBROS CICLOALQUILO(C3-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-AMINO-N
