Shwetal V. Mehta,Michael E. Berens,Harshil Dineshkumar Dhruv
申请号：
US14890685
公开号：
US20160102360A1
申请日:
2014.05.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to the identification of genetic signatures and expression profiles that are a part of the Base Excision Repair (BER) pathway, a major DNA repair pathway that modifies base lesions. In one embodiment, the present invention provides a method of determining responsiveness of treatment by BER inhibitors for malignant glioma by determining the presence of a low level of expression of Apex 1, a low level of expression of Apex 2, and a high level of expression of MPG.
