Seok-Hyung Kim,Do-Hyun Nam,Hyun-Kyu Park,Kyeung Min Joo,Nam Kyung Lee
申请号：
US14184960
公开号：
US09296817B2
申请日:
2014.02.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The antibody of the invention has high specificity to human c-Met and is cross-reactive to mouse c-Met. The antibody or its antigen-binding fragment of the invention is capable of specifically binding to human c-Met as well as mouse c-Met, more accurate preclinical results can be confirmed in the efficacy evaluation using mouse tumor models. The antibody of the invention inhibits the growth of cancer cells derived from various cancers by a considerable binding affinity to c-Met and the suppression of c-Met function therefrom, inhibits the phosphorylation of c-Met and downstream signaling molecules to suppress c-Met signaling, and inhibits neovascularization, thereby being very efficient in the prevention and treatment of cancers.
