1. A pharmaceutical composition comprising a compound of Formula I suitable for the treatment of syndrome Daunavklyuchaya isomers, stereoisomers, enantiomers, diastiomery, tautomers, pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof, wherein: each independently selected from the group consisting of H, F, Cl, Br, R, and -OR, wherein R is a substituted alkyl having 1-6 carbon atoms or an aryl or aralkyl group containing 6-14 carbon atoms R c is selected from O or S R is (CH) m, where m is 1 , 2 or 3 R c is selected from the group consisting of N and (CH), wherein n is 1 or 2 with the proviso that kogdaRpredstavlyaet is nitrogen, then in Rne m must be equal to 1 R is H each independently Ryavlyaetsya --X, --R, --OR, --SR, --N (R), --CN, --NO, --NC (O) R, --C (O) R, --C (O) N (R), --S (O) R, --S (O) NR, --S (O) R, --C (O) R, --C (O) oR, or --C (O) N (R) wherein each X independently is halogen ikazhdy R is independently H, alkyl, alkenyl, alkynyl, aryl, heterocycle, protecting group or prodrug moiety ifarmatsevticheski acceptable nositel.2. A pharmaceutical composition according to claim 1, characterized in that at least one Rotlichen from hydrogen and pharmaceutically acceptable nositel.3. A pharmaceutical composition according to claim 2, characterized in that Rmozhet either be the same as the other, or at least one Rotlichaetsya and a pharmaceutically acceptable nositel.4. A pharmaceutical composition according to claim 1, characterized in that the pharmaceutical compositions are suitable for suppressing Dyrk1a.5 activity. A method for treating Downs syndrome in a mammal comprising administering an effective amount of the pharmaceutical composition, said pharmaceutical composition comprising a pharmaceutically acceptable nositel.6. spo1. Фармацевтическая композиция, содержащая соединение Формулы I пригодная для лечения синдрома Даунавключая изомеры, стереоизомеры, энантиомеры, диастиомеры, таутомеры, фармацевтически приемлемые соли, гидраты, с
