An instrument guide (104) for a probe head (702) of an ultrasound imaging probe (106) that includes a transducer array (114) with a plurality of transducer elements (116) and an image plane. The instrument guide includes a probe support region (122) having a long axis (202) and configured to receive the probe head. The instrument guide further includes a first guide bracket (212) extending from a first side of the support region in a direction of the long axis. The instrument guide further includes a second guide bracket (230) extending from a second side of the support region in a direction transverse to the long axis. The instrument guide further includes a first guide (128) disposed in the first guide bracket. The instrument guide further includes a second guide (126) disposed in the second guide bracket.
