АДАМС Джерри Лерой (US),ДАФФИ Кевин Дж. (US),ЛЯНЬ Ицянь (US)
申请号：
RU2018103881
公开号：
RU2018103881A
申请日:
2016.12.01
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
A compound of Formula (VI) wherein R 58 and R 59 are independently selected from: H, CH 2 OC(O)R 57 , CH 2 OCO 2 R 57 , CH 2 CH 2 SC(O)R 57 , and CH 2 CH 2 SSCH 2 R 57 ； provided that at least one of R 58 and R 59 is not H； R 56 is F； X 51 O； X 52 is O. Pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.
