A microfluidic radiopharmaceutical production system and process for synthesizing per run approximately one (1) to four (4) unit dose of a radiopharmaceutical biomarker for use in positron emission tomography (PET). The system includes a reaction vessel that receives a radioisotope from an accelerator or other radioisotope generator. Organic and aqueous reagents are introduced into the reaction vessel, and the mixture is heated to synthesize a solution of a pre-selected radiopharmaceutical. The radiopharmaceutical solution is passed through a solid phase extraction column and a filter for purification. The synthesis process reduces waste and allows for the production of radiopharmaceutical on an as-needed basis. The synthesis process allows for production on-site and close to the location where the unit dose will be administered to the patient, which reduces time between synthesis and administration, thereby minimizing the loss of active isotopes through decay and allowing the production of lesser amounts of radioisotopes overall.
