您的位置: 首页 > 农业专利 > 详情页

Aminopyridyl ethylamine derivatives as the diagonal of methylamine h14 receptor
专利权人:
MEDICIS PHARMACEUTICAL CORPORATION
发明人:
CARCELLER GONZALEZ, ELENA,VIRGILI BERNADO, MARINA,SOLIVA SOLIVA, ROBERT,FERRER COSTA, CARLES
申请号:
PE2012000880
公开号:
PE20121505A1
申请日:
2010.12.22
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
1. A compound containing aminopyridine extracted from formula (I) with H1 as H or hydrocarbyl (C1-C4);R2 is acetyl butadiene, pyridine diene or propane, which is selectively replaced by tar (C1-C4);O R1 and R2, together with N atoms, form a single ring heterocycle group consisting of 4 to 7 members, 7 to 8 members can ride bicycles, or 8 to 12 alternative members can mix bicycles; R3 is h or tar (C1-C8);R4 is the tar (C1-C8) to be replaced by halogenated, cyclomethylated (C3-C10) - tar (c0-c4),Arilalquilo(C0-C4),R5 is h or tar (C1-C8), among others;N is 1 or 2. The most popular compounds are: 4 - ((cyclopropylmethylamine) - methyl) - 6 - (3 - (methylamine) acetamide-2-amine; 4 - ((2-methylamineptine) methyl) - 6 - (3 - (methylamine) acetamide-1-il); pyridine-2-amine; 4 - ((2, Di Di dichloropropyl) amine) - methylamine) - 6 - (3 - (methylamine) acetamide-1-pyridinedi; others. He also mentioned a preparatory process and a pharmaceutical composer. These compounds are antagonistic to H4 histamine receptor and are used in the treatment of asthma, allergic nephritis, dermatitis, skin rash and lupus.SE REFIERE A COMPUESTOS DERIVADOS DE AMINOALQUILPIRIMIDINA DE FORMULA (I) DONDE R1 ES H O ALQUILO(C1-C4); R2 ES ACETIDINILO, PIRROLIDINILO, PIPERIDINILO O ACEPANILO OPCIONALMENTE SUSTITUIDOS CON ALQUILO(C1-C4); O R1 Y R2 JUNTO AL ATOMO DE N AL QUE ESTAN UNIDOS FORMAN UN GRUPO HETEROCICLICO MONOCICLICO DE 4 A 7 MIEMBROS, BICICLICOS PUENTEADOS DE 7 A 8 MIEMBROS O BICICLICOS FUSIONADOS DE 8 A 12 MIEMBROS OPCIONALMENTE SUSTITUIDO; R3 ES H O ALQUILO(C1-C8); R4 ES ALQUILO(C1-C8) OPCIONALMENTE SUSTITUIDO CON HALOGENO, CICLOALQUILO(C3-C10)-ALQUILO(C0-C4), ARILALQUILO(C0-C4), ENTRE OTROS; R5 ES H O ALQUILO(C1-C8); n ES 1 O 2. SON COMPUESTOS PREFERIDOS: 4-((CICLOPROPILMETILAMINO)-METIL)-6-(3-(METILAMINO)ACETIDIN-1-IL)PIRIMIDIN-2-AMINA; 4-((2-ADAMANTILAMINO)METIL)-6-(3-(METILAMINO)ACETIDIN-1-IL)PIRIMIDIN-2-AMINA; 4-(((2,2-DIETILCICLOPROPIL)-METILAMINO)METIL)-6-(3-(METILAMINO)ACETIDIN-1-IL
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充