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A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN
专利权人:
CIPLA LIMITED
发明人:
CHIKHALIKAR, SANDIP VASANT,KANKAN, RAJENDRA NARAYANRAO,GHAGARE, MARUTI,RAO, DHARMARAJ RAMACHANDRA
申请号:
NZ59762010
公开号:
NZ597620A
申请日:
2010.08.18
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
597620 Disclosed herein is a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4) (b) converting the compound of formula (4) to a compound of formula (5) wherein Z is hydrogen or a benzyl group (c) converting the compound of formula (5) to naratriptan and (d) optionally converting naratriptan to a salt thereof. Also disclosed herein are compounds (3) and (4) and processes for their preparation.
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