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A process for the synthesis of naratriptan
专利权人:
Cipla Limited
发明人:
Rao, Dharmaraj Ramachandra,Kankan, Rajendra Narayanrao,Chikhalikar, Sandip Vasant,Ghagare, Maruti
申请号:
AU2010284832
公开号:
AU2010284832A1
申请日:
2010.08.18
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z' is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. The present invention also provides novel compounds (3) and (4) and processes for their preparation.
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