A method of adaptive image acquisition includes obtaining a guide image of patient tissue； receiving an intraoperative image of a portion of the patient tissue from an imaging instrument； and storing the intraoperative image. The method includes comparing the intraoperative image with the guide image to identify at least one region of the guide image matching the intraoperative image； and determining whether the at least one region identified meets at least one accuracy criterion. When the at least one region meets the at least one accuracy criterion, the guide image is rendered with an indication of the at least one region on a display. When the at least one region does not meet the at least one accuracy criterion, the method includes receiving and storing a further intraoperative image； combining the further intraoperative image with the intraoperative image； and repeating the comparing and determining.
