The invention provides a better pan TF Di antibody for the treatment of TGF Di transmitted diseases,Including autoimmune diseases, fiber diseases and cancer The invention provides an improved pan TGF - for treatment of conditions that are mediated by TGF -,including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.La invención proporciona un anticuerpo pan-TGF-ß mejorado para el tratamiento de afecciones que están mediadas por TGF-ß, incluyendo enfermedades autoinmunitarias, afecciones fibróticas, y cánceres. También se proporcionan usos y usos del anticuerpo junto con otros agentes inmunomoduladores tales como un anticuerpo anti-PD-1.The invention provides an improved pan-TGF-ß antibody for treatment of conditions that are mediated by TGF-ß, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.