BRITTELLI, DAVID R.,CURRIE, KEVIN S.,DARROW, JAMES W.,KROPF, JEFFREY E.,LEE, SEUNG H.,GALLION, STEVEN L.,MITCHELL, SCOTT A.,PIPPIN, DOUGLAS A. I.,BLOMGREN, PETER A.,STAFFORD, DOUGLAS GREGORY
申请号：
ES06737632
公开号：
ES2543607T3
申请日:
2006.03.09
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of Formula 2: ** Formula ** and pharmaceutically acceptable salts, solvates, chelates, non-colvalent complexes, prodrugs chosen from derivatives of acetate, format and benzoate of alcohol or amine groups, and mixtures thereof, in which R it is chosen from optionally substituted aryl and optionally substituted heteroaryl； M is a covalent bond, Q is chosen from ** Formula ** and in which R10 and R11 are independently selected from hydrogen, C1-C6 alkyl, and C1-C6 haloalkyl； and R12, R13, R14, and R15 are each independently selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, phenyl, substituted phenyl selected from mono-, di-, and tri-substituted phenyl, wherein the substituents are independently selected from hydroxy, nitro, cyano, amino, halo, C1-C6 alkyl, C1-C6 alkoxy, (C1-C6-oxy alkyl) C1-C6 alkoxy, C1-C6 perfluoroalkyl, perfluoroalkoxy of C1-C6, mono- (C1-C6 alkyl) amino, di (C1-C6 alkyl) amino, and amino (C1-C6 alkyl), heteroaryl, and substituted heteroaryl selected from heteroaryl mono-, di-, and tri- substituted, in which the substituents are independently selected from hydroxy, nitro, cyano, amino, halo, C1-C6 alkyl, C1-C6 alkoxy, (C1-C6-oxy alkyl) C1-C6 alkoxy, C1 perfluoroalkyl -C6, C1-C6 perfluoroalkoxy, mono- (C1-C6 alkyl) amino, di (C1-C6 alkyl) amino, and amino (C1-C6 alkyl), and Z is chosen from meta-phenylene and meta-phenylene substituted with an optionally substituted alkyl group selected or having one to four carbons, optionally substituted alkoxy having one to four carbons, halo, and hydroxy； and ** Formula ** in which Y is chosen from N and CR21； and R16, R21, and R22 are independently selected from hydrogen and optionally substituted alkyl having one to four carbons； and D is -NHR9, wherein R9 is chosen from optionally substituted aryl and optionally substituted heteroaryl.Un compuesto de Fórmula 2:**Fórmula** y sales farmacéuticamente aceptables, solvatos, quelatos, complejos no colvalentes, profármacos escogidos de derivados de ace
