Provided is a medicine feeding unit configured to feed solid medicines, the unit including: a medicine feeder having a medicine container configured to contain the medicines and a driven shaft provided rotatably to the medicine container, the medicine feeder being configured to feed the medicines from the medicine container by the driven shaft being rotationally driven; a support having a rotary drive source and a driving shaft that is connected coaxially with the driven shaft and that is rotationally driven by the rotary drive source, the support being configured to detachably support the medicine feeder, wherein the driven shaft has a driven shaft body and a driven engagement member that is movable in an axial direction relative to the driven shaft body, the driving shaft has a driving shaft body and a driving engagement member that is fixed to the driving shaft body and that is engaged with the driven engagement member, the driven engagement member is biased in an approaching direction approaching the driving engagement member, and the medicine feeding unit further includes a rotation preventing part configured to allow the driven engagement member to rotate in a mounted state in which the medicine feeder is mounted on the support and to prevent the driven engagement member from rotating in a detached state in which the medicine feeder is detached from the support.