The disclosure provides a method of immunotherapy for a cancer patient, comprises administering vaccines against Globo series antigens (i.e., Globo H, Stage-specific embryonic antigen 3 “SSEA3” and Stage-specific embryonic antigen 4 “SSEA4”). Specifically, the method comprises administering Globo H-KLH (OBI-822) in patients with Metastatic Breast Cancer. The disclosure also provides a method of comprises selecting a cancer patient who is suitable as treatment candidate for immunotherapy. In addition, the disclosure provides therapeutic agents, including monoclonal antibodies (mAbs) that bind specifically to Globo series antigens and related biomarkers useful in focusing such therapeutic and diagnostic regimens.本發明提供了一種針對癌症患者的免疫治療方法，包含投予Globo系列抗原（即，Globo H、階段特異性胚胎抗原3「SSEA3」以及階段特異性胚胎抗原4「SSEA4」）的疫苗。具體而言，該方法包含在轉移性乳癌患者中投予Globo H-KLH （OBI-822）。本發明亦提供一種方法，其包含選擇適合作為免疫治療的治療候選人的癌症患者。此外，本發明提供治療藥劑，包括特異性結合Globo系列抗原的單株抗體（mAb）以及可用於聚焦此種治療及診斷方案的相關生物標記。
