This application relates to cosmetic methods for improving skin conditions. The methods generally include the administration of platelet-rich plasma and cultured autologous cells to a subject after a micro-needling procedure has been performed. The platelet-rich plasma and autologous cells can be topically applied to the skin surface or injected into the dermis or subcutaneous tissue. The methods may be used to improve conditions such as acne scars, traumatic scars, hyperpigmentation, fine lines, wrinkles, stretch marks, and hair loss.