The invention relates to a gel composition comprising chlorhexidine and/or a pharmaceutically acceptable salt thereof; hyaluronic acid and/or a pharmaceutically acceptable salt thereof; and a gelling matrix, wherein the gelling matrix comprises water, and cellulose derivatives. The invention also relates to a method for preparing the gels and to particular uses of the gels in the field of oral cavity cosmetics, hygiene, prevention of oral cavity diseases and treatment of said diseases.