A process for preparation of thiocyclam base and salt. A method of manufacturing N,N-dimethy1-1,2,3-trithian-5-ylainine hydrochloride is described including the steps of: providing a mixture of thiosulfuric acid S, S’-[2-(dimethylarnino) trimethylene] ester monosodium salt and sodium hydroxide； adding an aqueous saline solution to the mixture of thiosulfuric acid S, S’-[2-(dimethylarnino) trimethylene] ester monosodium salt and sodium hydroxide； separating the phases of the mixture； collecting the solids from the mixture using filtration； washing the solids with organic solvent； and drying the solids, where the dried solids are N,N-dimethy1-1,2,3-trithian-5-ylamine hydrochloride, and where the yield of the N,N-dimethy1-1,2,3-trithian-5-ylamine hydrochloride is increased by incorporation of a body charge of diatomaceous earth into the saline addition step, forming a mixture of the diatomaceous earth with the composition of this step, and filtering the charged mixture through a diatomaceous earth media prior to the separation step.一種用於製備硫賜安鹼及鹽之程序。描述一種製造N,N-二甲基-1,2,3-三噻-5-基胺鹽酸鹽之方法，其包括下列步驟：提供硫代硫酸S, S’- [2-(二甲基胺基)三亞甲基]酯單鈉鹽與氫氧化鈉之混合物；將鹽水溶液添加至硫代硫酸S, S’- [2-(二甲基胺基)三亞甲基]酯單鈉鹽與氫氧化鈉之該混合物；分離該混合物之該等相；使用過濾自該混合物收集固體；用有機溶劑洗滌該等固體；及乾燥該等固體，其中該等經乾燥固體係N,N-二甲基-1,2,3-三噻-5-基胺鹽酸鹽，並且其中該N,N-二甲基-1,2,3-三噻-5-基胺鹽酸鹽之產率係藉由下列方式來提高：將矽藻土之主體進料結合至該鹽水添加步驟，從而形成該矽藻土與此步驟之該組成物的混合物；及在該分離步驟之前使該經進料之混合物過濾通過矽藻土介質。
