PROBLEM TO BE SOLVED: To provide a vector for astrocyte-specifically and efficiently expressing a gene.SOLUTION: The glial cell-specific expression vector includes a promoter comprising a base sequence which is a continuous base sequence within a range of from -300 to +14 when the transcription-starting point of a mouse glial fibrillary acidic protein (GFAP) gene is taken as +1, and which includes at least a region of from -132 to -58, or a promoter comprising a base sequence which is a continuous base sequence within a range of from -286 to +14 when the transcription-starting point of a human GFAP gene is taken as +1, and which includes at least a region of from -119 to -57, and a target gene arranged downstream thereof.【課題】アストロサイト特異的に効率よく遺伝子を発現させるベクターを提供すること。【解決手段】マウスGlial fibrillary acidic protein (GFAP)遺伝子の転写開始点を＋１として数えて-300～+14の領域内の連続した塩基配列であって少なくとも-132～-58の領域を含む塩基配列からなるプロモーターまたはヒトGFAP遺伝子の転写開始点を+1として数えて-286～+14の領域内の連続した塩基配列であって少なくとも-119～-57の領域を含む塩基配列からなるプロモーターと、その下流に配置された目的遺伝子を含む、グリア細胞特異的発現ベクター。【選択図】図３
