SCHOEN, PIETER JOSEPH,KERSTEN, ALEXANDER JEROEN,MEDEMA, JEROEN KRISTIAAN,THUS, JOHANNES LAMBERTUS GERARDUS
申请号：
MX2011012587
公开号：
MX2011012587A
申请日:
2010.05.26
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
The present invention belongs to the field of pharmaceutical industry and specifies a method for testing extraneous agents in a composition comprising at least one active agent, comprising the steps of: a) contacting an antibody, which had been raised against an expression product of a polynucleotide construct comprising a sequence encoding at least a part of the active agent, with the composition comprising at least one active agent, wherein the antibody binds to the active agent, and b) determining the presence or absence of extraneous agents in the composition subsequent to step a). Furthermore, the invention specifies a process for producing a pharmaceutical composition by carrying out said method, to the use of a polynucleotide construct for testing the presence or absence of the active agent or of any extraneous or infectious agent in a composition to be tested. The present invention also relates to particular polynucleotides and polynucleotide constructs as useful substances in the field of influenza vaccines, as well as non-human organisms, transgenic animals or microorganisms containing the polynucleotides and/or polynucleotide constructs. The present invention is also directed to kit of parts.La presente invención pertenece al campo de la industria farmacéutica y especifica un método para analizar agentes extraños en una composición que comprende al menos un agente activo, que comprende las etapas de: a) poner en contacto un anticuerpo, que se ha cultivado contra un producto de expresión de un constructo de polinucleótido que comprende una secuencia de codificación de al menos una parte del agente activo, con la composición que comprende al menos un agente activo, en donde el anticuerpo se une al agente activo y b) determinar la presencia o ausencia de agentes extraños en la composición posterior al paso a) además, la invención especifica un procedimiento para producir una composición farmacéutica al realizar dicho método, para el uso de un constructo de p
