STEIN, David A.,RIJNBRAND, Cornelis A.,IVERSEN, Patrick L.,WELLER, Dwight D.
申请号：
AU2013205445
公开号：
AU2013205445B2
申请日:
2013.04.26
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2013205445B220160721.pdf#####Abstract The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, including partially positively charged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5' untranslated region identified by SEQ ID NO:4.
