In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices for treating, preventing or ameliorating a tumor or a cancer, and methods for treating, preventing or ameliorating a tumor or a cancer. In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices comprising: a beta adrenergic receptor antagonist (a “beta blocker”) a non-steroidal anti-inflammatory drug (a NSAID) and a therapeutic agent, compound or composition comprising: a H2-receptor antagonist (H2RA), a melatonin (or an N-acetyl-5-methoxy-tryptamine), a metformin, a quinoline (e.g., chloroquine), an immune checkpoint blockade agent, or an agent that blocks the interaction between a transmembrane programmed cell death 1 protein, or any combination thereof. In alternative embodiments, the therapeutic combinations of therapeutic agents or drugs further comprise an anti-cancer or anti-tumor antibody, a cytokine, and/or a chemotherapeutic agent.
