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TETRAHYDROBENZACEPINS AND ITS USE IN THE MODULATION OF THE DOPAMINE D3 RECEPTOR.
专利权人:
ABBOTT GMBH & CO. KG
发明人:
BRAJE, WILFRIED,HAUPT, ANDREAS,LUBISCH, WILFRIED,GRANDEL, ROLAND,DRESCHER, KARLA,GENESTE, HERVE,UNGER, LILIANE,SAUER, DARYL
申请号:
ES04820441
公开号:
ES2375963T3
申请日:
2004.12.17
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A tetrahydrobenzacepin of the general formula I wherein Ar is an aromatic radical which is selected from phenyl and a heteroaromatic radical, with 5 or 6 members, having 1, 2, 3 or 4 heteroatoms which are independently selected from each other of O , N and S, where the aromatic radical may have 1, 2 or 3 substituents which are independently selected from each other of C1-C6 alkyl which is optionally substituted one or more times by OH, C1-C4 alkoxy, halogen or phenyl, C2-C6 alkenyl which is optionally substituted one or more times by OH, C1-C4 alkoxy, halogen or phenyl, or C2-C6 alkynyl which is optionally substituted one or more times by OH, C1-C4 alkoxy, halogen or phenyl, or C3-C6 cycloalkyl which is optionally substituted one or more times by OH, C1-C4 alkoxy, halogen or phenyl or C1-C4 alkyl, or halogen, CN, OR4, COOR4, NR5R6, CONR5R6, NO2, SR7, SO2R7, SO2NR5R8, COR8, and phenyl which optionally has one, two or tr it is substituents which are independently selected from each other of C1-C4 alkyl, C1-C4 alkoxy, NR5R6, CN, C1-C2 fluoroalkyl or halogen, where the phenyl and the heterocyclic radical can also be fused to an aromatic or non-aromatic carbocycle , with 5 or 6 members, or the phenyl can be fused to an aromatic or non-aromatic heterocycle, with 5 or 6 members, which has 1, 2 or 3 heteroatoms selected from O, N and S; R1 is hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C8 alkynyl, C2-C8 haloalkynyl, C1-C8 alkylcarbonyl, C1-C8 haloalkylcarbonyl or substituted C1-C8 alkyl which carries a substituent which is selected from OH, C1-C4 alkoxy, C1-C4 alkylamino, di- (C1-C4 alkyl) amino, phenyl, phenoxy, C3-C8 cycloalkyl and C3 cycloalkyloxy -C8, where the last four groups mentioned optionally may have one or more substituents selected from OH, CN, NO2, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy and halogen; R2 is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, OH, NO2, CN, COOR4, N
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