RITTENHOUSE OLSON KATE,ABDULLAH JULIA,ENG JING YING,KOURY STEPHEN T
申请号：
IN201617036729
公开号：
IN201617036729A
申请日:
2016.10.26
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Provided are humanized monoclonal antibodies (mAbs) or fragments thereof that bind with specificity to the Thomsen Friedenreich (TF) human tumor antigen. Three distinct variable heavy and three variable light chains are provided and can be combined to make a total of twenty five distinct heavy and light chain combinations. Methods of using the mAbs and fragments thereof for cancer therapy and diagnostic imaging are provided as are methods for making the mAbs and fragments thereof. In vitro cell cultures that express the mAbs and fragments thereof and kits are also provided.
