ROSA CALATRAVA MANUEL,TRAVERSIER AURLIEN,DESUZINGES MANDON ‰LODIE,DEJEAN EMMANUEL
申请号：
IN201717010452
公开号：
IN201717010452A
申请日:
2017.03.24
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention relates to a method for preparing a vaccine antigen which includes a step of fragmenting a biological membrane associated with said vaccine antigen by treating said biological membrane with at least one calixarene of formula (II): wherein: X is a (CH2) CO2Y group and Y is an alkaline metal or one of the pharmaceutically acceptable salts thereof wherein said resulting vaccine antigen also includes a fragment of the biological membrane associated with said antigen. The present invention also relates to a vaccine that can be produced by implementing the method including a calixarene of formula (II) in carrier format with a quantity of 0.1 to 1 000 µg in the total weight of the vaccine. The present invention further relates to the use of a calixarene as defined above for the preparation of a vaccine or a vaccine antigen and to the vaccine for use as a drug in the treatment or prevention of an infectious disease.
